Treatment of carcinoma in situ of the glans penis with. A relatively rare precancerous lesion was described as early as 1893 by fournier and darier. The use of topical agents in the treatment of carcinoma in situ cis of the. Fiveyear disease free survival rates of 95100% have been reported in surgically staged patients with negative lymph nodes. Affected individuals develop a reddish, velvety or smooth plaque. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Penile melanosis is the most common cause of dark spots on the penis. Erythroplasia of queyrat treated with imiquimod 5% cream. Include erythroplasia of queyrat erythematous plaque on the glans and prepuce and bowens disease scaly hyperkeratotic plaque, usually on shaft of penis usually in 40s to 60s. The patient was free from recurrence 11 months after cessation of the therapy. An external preparation of imiquimod therapy may be one of the most useful. Keywords erythroplasia of queyrat, zoons balanitis, balanoposthitis, dysplasia.
Erythroplasia of queyrat is also known as bowen disease of the glans penis, although the latter term actually refers to the condition on the outer keratinized surface of the penis. Inaddition hand searches were performed for the main oral medicine journals and books on oral mucosal diseases. Methods paraffinembedded biopsies were obtained from the. Erythroplasia of queyrat is a type of skin cancer of the penis. Erythroplasia of queyrat treated with 5% imiquimod cream. Erythroplasia of queyrat eq is an in situ squamous cell carcinoma of the penis. Squamous cell cancer accounts for more than 95% of cases of penile cancer. Introduction erytroplasia queyrat eq is a rare disease which arises from the squamous epithelial cells of the glans penis or inner lining of the prepuce. Its histology and behaviour are identical to bowens disease of skin. Queyrat erythroplasia accompanied by bladder cancer in a circumcised male savas ozturk, haydar ucak elazig education and research hospital dermatology department, elazig 23100, turkey. Penile melanosis, penile lentigo, and seborrheic keratosis comprise the differential diagnosis of dark spots on the penis and also should be kept in mind.
Given the size and location of the lesion, preventing the surgical option, we performed the treatment with co2 laser. The lesions on glans penis and prepuce were asymptomatic. This case suggests topical imiquimod might be a candidate with regimens consisting of much longer duration of the treatment than for genital warts and the maintenance phase of the treatment course to prevent the relapse. Pinpoint erythematous spots or cayenne pepper spots may also be associated with this condition. Erythropoiesis definition of erythropoiesis by medical.
Development of noninvasive treatments for erythroplasia of queyrat, a carcinoma in situ, is expected. Erythroplakia diseases and disorders clinical medicine. A case of erythroplasia of queyrat treated with imiquimod. Erythroplasia of queyrat, and lbowenoid papulosis b3p lesions. Erythroplasia of queyrat of the glans penis on a background of zoons plasma cell balanitis. Two cases of erythroplasia of queyrat with persistent posttreatment inflammation after histological remission of epithelial dysplasia.
Zoon 1952 reported 8 cases of a benign inflammatory balanitis which he differentiated from erythroplasia of queyrat. Treatment of cutaneous tumors with topical 5% imiquimod cream. It is seen in uncircumcised men aged 2080 years and represents an in situ form of squamous cell carcinoma. Furthermore, fixed drug eruption, allergic contact dermatitis, genital herpes, pemphigus vulgaris, flexural psoriasis, and reiters disease should be. Erythroplasia of queyrat an overview sciencedirect topics.
Defined as the inflammation of the foreskin and glans in uncircumcised males, balanoposthitis occurs over a wide age range and may have any of multiple bacterial or fungal origins or be caused by contact dermatitides. Human papillomavirus type 16 dna has previously been detected only in very few distinctly characterized patients. However, the exact relation between hpv and erythroplasia of queyrat eq, for example, insitu carcinoma of the glans and prepuce, is still unclear. Pdt in the treatment of erythroplasia of queyrat dermatology 2011. First described by the american dermatologist john t. Erythroplasia of queyrat bowen disease of the glans penis. Erythroplasia of queyrat is a carcinoma in situ that mainly occurs on the glans penis, the prepuce, or the urethral meatus of elderly males. Erythroplasia of queyrat eq is a carcinoma in situ that appears as a well. Abstract observations from 100 men with erythroplasia of queyrat eq indicate that the disease is a distinct clinicopathologic entity. The lesions cleared completely, and recurrence free followup periods ranged from 20 to 60 months.
The authors of this retrospective study from england soughtto determine if there is an association between penile. Erythroplasia of queyrat, and bowenoid papulosis bp lesions. Thw aim of this study was to detect the presence of lesional hpvdna in patients with eq. Hepcidin synthesis is directed by numerous elements apart from inflammation, including iron stores, hypoxia and erythropoiesis, and hepcidin release into the peripheral circulation is regulated by other proteins, including hjv, hereditary haemochromatosis protein, transferrin receptor 2, matriptase2 and neogenin. In 1933, sulzberger and satenstein recognized erythroplasia of queyrat as a form of carcinoma in situ. Erythroplasia of queyrat should be diagnosed in a noncompliant patient based on the clinical picture and hpv testing even in the absence of a biopsy, and a nonsurgical treatment should be. Bowenoid papulosis also has a lower malignancy potential than erythroplasia of queyrat and bowen disease. Considered precursor in situ lesions of squamous cell carcinoma.
Use of images for any purpose including but not limited to research, commercial, personal, or noncommercial use is prohibited without prior written consent. Another french author, queyrat, 4 in 1911 devoted himself to a more exhaustive study of the condition and gave it the name of erythroplasie. Erythroplasia of queyrat and bowens disease of the penis. Two cases of erythroplasia of queyrat with persistent post. A clinicopathologic and histochemical study erythroplasia of queyrat. Pdf erythroplasia of queyrat treated with topical 5fluorouracil. The duration of the disease was unknown in two cases, oneyearin twocases, and 12, 15. Fu is the treatment of choice for histologically confirmed eq. Erythroplakia is a clinical term to describe any erythematous red area on a mucous membrane, that cannot be attributed to any other pathology 805 the term erythroplasia was coined by louis queyrat to describe a precancerous red lesion of the penis. A patient with erythroplasia of queyrat may require surgery to remove the cancerous penis skin.
At a later date 1911, queyrat 2 described in detail several cases of what was apparently an identical condition. Bowen in 1912, bowen disease is a squamous cell carcinoma scc in situ with the potential for significant lateral spread. It mainly occurs in uncircumcised males, over the age of 40. Article information, pdf download for erythroplasia of queyrat with zoons. It is reported to occur in the corneoscleral limbus. Because of the bowenoid histologic features, some observers believe that. Queyrat erythroplasia accompanied by bladder cancer in a.
Abnormal cells are found on the surface of the skin of the penis. Erythroplasia of queyrat was originally described by tarnovsky in 1891 and later appreciated as a penile disease by fournier and darier in 1893. The cause of erythroplasia of queyrat is largely unknown. Tarnovsky originally described erythroplasia of queyrat in 1891, but it was queyrat who coined the term erythroplasia in 1911. Three patients with biopsyconfirmed erythroplasia of queyrat were treated with topically applied fluorouracil. Doctors may conduct a biopsy on a erythroplasia of queyrat to remove tissue and examine it under a microscope. Erythroplasia of queyrat is a premalignant disease. Erythroplakia free download as powerpoint presentation. Response to treatment was assessed by clinical examination, 5%. Erythroplasia of queyrat is commonly seen in older men. This gave rise to the term erythoplasia of queyrat. Clinical practice guideline alberta health services. Squamous cell carcinoma in situ on the penile mucosa or transitional surfaces is also known as erythroplasia of queyrat.
Penile intraepithelial neoplasia american urological. Objectives highrisk human papillomavirus hpv types have been linked with genital carcinomas. Depending upon the context, this term may refer specifically to carcinoma in situ of the. Erythrophagocytosis definition of erythrophagocytosis by. Dermnet does not provide medical advice, diagnosis or treatment. Pimecrolimus, a calcineurin inhibitor which is a homologous counterpart of tacrolimus, has also been used for treatment by bardazzi et al 9 in two patients with good response, and by stinco et al 10 in three cases, with different results. Zoons balanitis diagnosis and followup hota d, basu r. Erythroplasia of queyrat is a carcinoma in situ that mainly occurs on the glans penis. Erythroplasia of queyrat is a particular type of bowens disease that can arise on the glans or prepuce in males. In the region, one third of penile squamous cell carcinoma in situ cases progress to invasive squamous cell carcinoma.
Basaloid and warty pein is hpvrelated particularly hpv16 and 18. Erythroplasia of queyrat may also occur on the anal mucosa or the oral mucosa. Ifonlythesearchwordoralerythroplakiawasused183itemsweremonitored. Erythroplasia of queyrat eq, bowens disease of the penis.
Observations from 100 men with erythroplasia of queyrat eq indicate that the disease is a distinct. Erythroplasia of queyrat eq or squamous cell carcinoma in situ of the glans penis developed in a 79 year old uncircumsised gentleman who had a six year prior history of biopsy proven zoons. A clinicopathologic and histochemical study graham, james h helwig, elson b. Methylaminolaevulinic acid photodynamic therapy in the. Darier accepted this new name, and the disease is now generally known as the erythroplasie, erythroplasia, erythroplakie or erythroplakia of queyrat. There are several noninvasive treatment options for erythroplasia of queyrat such as photodynamic therapy, cryosurgery and applying various kinds of topical agents. Erythroplasia of queyrat scc in situ of the glans or prepuce in males, m.
Here, we present our experience in the treatment of 123 cutaneous tumors of various types, including basal cell carcinoma bcc, squamous cell carcinoma scc, bowens disease, erythroplasia of queyrat, pagets disease, and trichoepithelioma, with 5% imiquimod cream from 2003 to 2008 in the cutaneous oncology group of the dermatology. Larger lesions can reach several centimeters in diameter. There were normal histological findings in posttreatment biopsy specimens in. International and consumer assistance at its toll free number 800 6382041 or 301 7967100 or at its internet address. Scribd is the worlds largest social reading and publishing site. Erythroplasia of queyrat jama dermatology jama network. A case is reported in which the diagnosis was established by biopsy and which was treated by excision and repair with a free skin graft. There were normal histological findings in posttreatment. The lesions cleared completely, and recurrencefree followup periods ranged from 20 to 60 months. Treatment of carcinoma in situ of the glans penis with topical. The presence of a foreskin is a wellknown risk factor for penile squamous cell carcinoma, erythroplasia of queyrat, and sexually transmitted diseases. Complex infections have been well documented, often from a poorly retractile foreskin and poor hygiene that leads to colonizat. Erythroplasia of queyrat is a rare in situ carcinoma of the uncircumcised man and its treatment depends on the extent and location of the lesion. Studies by queyrat in 1911 allowed erythroplasia of queyrat to be accepted as a distinct entity.
724 1257 287 530 951 842 1220 1100 1078 507 97 884 181 474 159 1288 226 1673 1611 1567 132 806 984 1400 928 546 81 11 49 491 1243 670 1673 110 902 1676 1271 361 7 839 734 738 542 1482 1120 536 854 960 1216 547 581